Modulation of intracranial meningeal nociceptor activity by cortical spreading depression: a reassessment

Modulation of intracranial meningeal nociceptor activity by cortical spreading depression: a reassessment.

Cortical spreading depression (CSD), a putative migraine trigger, has been shown recently to promote multiple activation patterns of meningeal nociceptors. In the current study we used a modified experimental approach in a rat model to: 1) reassess the responses of meningeal nociceptors following a single CSD episode, 2) examine factors that may influence the propensity of meningeal nociceptors...

Modulation of intracranial meningeal nociceptor activity 1 by cortical spreading depression

Cortical Spreading Depression Promotes Persistent Mechanical Sensitization of Intracranial Meningeal Afferents: Implications for the Intracranial Mechanosensitivity of Migraine

Migraine is one of the most common and disabling diseases in the world. A major feature of migraine headache is its aggravation by maneuvers that momentarily increase intracranial pressure. A key hypothesis implicates mechanical sensitization of trigeminal afferents that innervate the intracranial meninges in mediating this feature of migraine. However, whether such pain-related neural response...

Activation of meningeal nociceptors by cortical spreading depression: implications for migraine with aura.

Attacks of migraine with aura represent a phenomenon in which abnormal neuronal activity in the cortex produces sensory disturbances (aura) some 20-40 min before the onset of headache. The purpose of this study was to determine whether cortical spreading depression (CSD)--an event believed to underlie visual aura--can give rise to activation of nociceptors that innervate the meninges--an event ...

P 23: Apoptosis Following Cortical Spreading Depression in Juvenile Rats

Introduction: Repetitive cortical spreading depression (CSD) can lead to cell death in immature brain tissue. Caspases are involved in neuronal cell death in several CSD-related neurological disorders. Yet, whether repetitive CSD itself can induce caspase activation in adult or juvenile tissue remains unknown. Inducing repetitive CSD in somatosensory cortices of juvenile and adult rats in vivo,...